3/04 Inflammation and Fatigue in Neurodivergent Populations

Based on: Eccles et al. (2023) The neuroimmune link: Inflammation and fatigue in neurodivergent populations — Frontiers in Neuroscience

Fatigue, brain-fog, and burnout are not just psychological—they’re physiological. Eccles et al. connect neurodivergence to immune dysregulation, showing that inflammation may play a central role in cognitive and emotional exhaustion.

We’ll discuss:

• The emerging evidence for a neuro-immune model of fatigue.

• Cytokines, microglia, and neuroinflammation: what’s happening on a cellular level.

• How chronic immune activation may explain sensory overload, brain-fog, and emotional volatility.

• Why these findings could reshape treatment for ADHD, ME/CFS, and post-viral syndromes.